(*): W=Win, N=Nomination
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2001 | N | Funniest Female Performer in a TV Series (Leading Role) Network, Cable or Syndication | Will & Grace (1998) | - |
| 2000 | N | Funniest Female Performer in a TV Series (Leading Role) Network, Cable or Syndication | Will & Grace (1998) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2019 | N | Best Actress in a Drama Series | Will & Grace (1998) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2007 | N | Outstanding Lead Actress in a Miniseries or a Movie | The Starter Wife (2007) (TV) | - |
| 2006 | N | Outstanding Lead Actress in a Comedy Series | Will & Grace (1998) | - |
| 2003 | W | Outstanding Lead Actress in a Comedy Series | Will & Grace (1998) | - |
| 2002 | N | Outstanding Lead Actress in a Comedy Series | Will & Grace (1998) | - |
| 2001 | N | Outstanding Lead Actress in a Comedy Series | Will & Grace (1998) | - |
| 2000 | N | Outstanding Lead Actress in a Comedy Series | Will & Grace (1998) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2017 | W | - | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2019 | N | Best Performance by an Actress in a Television Series - Musical or Comedy | Will & Grace (1998) (TV) | - |
| 2009 | N | Best Performance by an Actress in a Television Series - Musical or Comedy | The Starter Wife (2007) (TV) | - |
| 2008 | N | Best Performance by an Actress in a Mini-series or Motion Picture Made for Television | The Starter Wife (2007) (TV) | - |
| 2005 | N | Best Performance by an Actress in a Television Series - Musical or Comedy | Will & Grace (1998) | - |
| 2004 | N | Best Performance by an Actress in a Television Series - Musical or Comedy | Will & Grace (1998) | - |
| 2003 | N | Best Performance by an Actress in a Television Series - Musical or Comedy | Will & Grace (1998) | - |
| 2002 | N | Best Performance by an Actress in a Television Series - Musical or Comedy | Will & Grace (1998) | - |
| 2001 | N | Best Performance by an Actress in a TV-Series - Comedy/Musical | Will & Grace (1998) | - |
| 2000 | N | Best Performance by an Actress in a TV-Series - Comedy/Musical | Will & Grace (1998) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2015 | N | Favorite Actress in a New TV Series | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2009 | N | Worst Actress | The Women (2008) | Annette Bening, Eva Mendes, Jada Pinkett-Smith, Meg Ryan |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2008 | N | Actress in a Motion Picture, Comedy or Musical | "Nothing Like the Holidays" | - |
| 2007 | N | Best Actress in a Miniseries or a Motion Picture Made for Television | The Starter Wife (2007) (TV) | - |
| 2004 | N | Best Performance by an Actress in a Series, Comedy or Musical | Will & Grace (1998) | - |
| 2003 | W | Best Performance by an Actress in a Series, Comedy or Musical | Will & Grace (1998) | - |
| 2002 | W | Best Performance by an Actress in a Series, Comedy or Musical | Will & Grace (1998) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2008 | N | Outstanding Performance by a Female Actor in a Television Movie or Miniseries | The Starter Wife (2007) (TV) | - |
| 2005 | N | Outstanding Performance by an Ensemble in a Comedy Series | Will & Grace (1998) | Sean Hayes, Eric McCormack, Megan Mullally |
| 2004 | N | Outstanding Performance by a Female Actor in a Comedy Series | Will & Grace (1998) | - |
| 2004 | N | Outstanding Performance by an Ensemble in a Comedy Series | Will & Grace (1998) | Sean Hayes, Eric McCormack, Shelley Morrison |
| 2003 | N | Outstanding Performance by an Ensemble in a Comedy Series | Will & Grace (1998) | Sean Hayes,Megan Mullally, Eric McCormack |
| 2002 | N | Outstanding Performance by an Ensemble in a Comedy Series | Will & Grace (1998) | Sean Hayes,Megan Mullally, Eric McCormack |
| 2001 | W | Outstanding Performance by an Ensemble in a Comedy Series | Will & Grace (1998) | Sean Hayes, Eric McCormack, Megan Mullally |
| 2001 | N | Outstanding Performance by a Female Actor in a Comedy Series | Will & Grace (1998) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2002 | N | TV - Choice Actress, Comedy | Will & Grace (1998) | - |
| 2001 | N | TV - Choice Actress | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2001 | W | Actress of the Year in a Comedy Series | Will & Grace (1998) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2000 | N | Best Actress in a Quality Comedy Series | Will & Grace (1998) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2017 | W | Television (On October 6, 2017. At 6201 Hollywood Blvd.) | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2005 | W | - | - | - |
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