In the treacherous feudal era of Japan, a lone and cynical ninja-for-hire, Jubei Kibagami, finds his life of detachment violently upended when he is poisoned and forced into a deadly mission. His reluctant guide is the mysterious Kagero, a government spy whose very touch is lethal, and together they are compelled by the shadowy official Dakuan to investigate a sinister plague. They soon discover the horrifying truth: the epidemic is a weapon wielded by the Eight Devils of Kimon, a band of superhuman assassins with terrifying powers, who serve a dark ambition that threatens the entire nation. Directed by Yoshiaki Kawajiri, this seminal action thriller plunges viewers into a gorgeously animated world of visceral combat and supernatural horror, where Koichi Yamadera's Jubei must confront not only monstrous foes but also the ghosts of his own past. As the body count rises and loyalties are tested, Jubei and Kagero must navigate a labyrinth of betrayal to face a conspiracy that reaches into the highest echelons of power.