| Rank | Week-1 | Movie Title | Total Gross | ||
| 1 |
|
|
 Transformers: Revenge of the FallenShia LaBeouf, Megan Fox
|
$108,966,307 | $200,077,255 |
| 2 |
 |
|
The ProposalSandra Bullock, Ryan Reynolds
|
$18,578,541 | $69,162,471 |
| 3 |
|
|
The HangoverBradley Cooper, Ed Helms
|
$17,022,166 | $183,054,267 |
| 4 |
|
|
UpEdward Asner, Jordan Nagai
|
$13,061,737 | $250,234,554 |
| 5 |
|
|
My Sister's KeeperSofia Vassilieva, Abigail Breslin
|
$12,442,212 | $12,442,212 |
| 6 |
|
|
Year OneJack Black, Michael Cera
|
$6,022,444 | $32,529,560 |
| 7 |
|
|
The Taking of Pelham 123Denzel Washington, John Travolta
|
$5,451,107 | $53,456,827 |
| 8 |
|
|
Star TrekChris Pine, Zachary Quinto
|
$3,711,968 | $246,331,182 |
| 9 |
|
|
Night at the Museum 2: Battle of the SmithsonianBen Stiller, Amy Adams
|
$3,643,522 | $163,391,192 |
| 10 |
 |
|
Away We GoJohn Krasinski, Maya Rudolph
|
$1,709,313 | $4,088,390 |
| 11 |
|
|
Land of the LostWill Ferrell, Anna Friel
|
$1,195,685 | $46,815,665 |
| 12 |
|
|
Angels & DemonsTom Hanks, Ayelet Zurer
|
$1,091,953 | $130,277,166 |
| 13 |
|
|
Terminator SalvationChristian Bale, Sam Worthington
|
$1,088,392 | $121,925,747 |
| 14 |
|
|
Imagine ThatEddie Murphy, Yara Shahidi
|
$942,273 | $14,067,015 |
| 15 |
|
|
Drag Me to HellAlison Lohman, Justin Long
|
$583,215 | $40,536,230 |
| 16 |
|
|
New YorkJohn Abraham, Katrina Kaif
|
$467,694 | $467,694 |
| 17 |
|
|
CheriMichelle Pfeiffer, Kathy Bates
|
$405,701 | $405,701 |
| 18 |
|
|
Monsters vs. AliensReese Witherspoon, Paul Rudd
|
$365,080 | $195,984,055 |
| 19 |
|
|
Whatever WorksLarry David, Evan Rachel Wood
|
$359,805 | $738,969 |
| 20 |
|
|
X-Men Origins: WolverineHugh Jackman, Liev Schreiber
|
$310,167 | $177,836,819 |
