(*): W=Win, N=Nomination
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2007 | N | Best Supporting Actor | X-Men: The Last Stand (2006) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2001 | N | Funniest Male Performer in a TV Series (Leading Role) Network, Cable or Syndication | Frasier (1993) (TV) | - |
| 1999 | N | Funniest Male Performer in a TV Series (Leading Role) Network, Cable or Syndication | Frasier (1993) (TV) | - |
| 1996 | W | Funniest Male Performer in a TV Series (Leading Role) Network, Cable or Syndication | Frasier (1993) (TV) | - |
| 1995 | W | Funniest Male Performer in a TV Series (Leading Role) Network, Cable or Syndication | Frasier (1993) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2001 | W | Sir Peter Ustinov Award | Kesley Grammer | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2012 | N | Best Actor in a Drama Series | Boss (2011) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2017 | W | Outstanding Performer in an Animated Program | Trollhunters | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 1999 | N | Outstanding Directorial Achievement in Comedy Series' | Frasier (1993) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2006 | W | Outstanding Voice-Over Performance | The Simpsons (1989) (TV) | - |
| 2004 | W | Outstanding Lead Actor in a Comedy Series | Frasier (1993) | - |
| 2002 | N | Outstanding Lead Actor in a Comedy Series | Frasier (1993) (TV) | - |
| 2001 | N | Outstanding Comedy Series | Frasier (1993) (TV) | David Angell, Peter Casey, David Lee (executive producer) |
| 2001 | N | Outstanding Lead Actor in a Comedy Series | Frasier (1993) (TV) | - |
| 2000 | N | Outstanding Comedy Series | Frasier (1993) (TV) | David Angell, Peter Casey, David Lee (executive producer) |
| 2000 | N | Outstanding Lead Actor in a Comedy Series | Frasier (1993) (TV) | - |
| 1999 | N | Outstanding Lead Actor in a Comedy Series | Frasier (1993) (TV) | - |
| 1999 | N | Outstanding Comedy Series | Frasier (1993) (TV) | David Angell, Peter Casey, David Lee (executive producer) |
| 1998 | W | Outstanding Lead Actor in a Comedy Series | Frasier (1993) (TV) | - |
| 1997 | N | Outstanding Lead Actor in a Comedy Series | Frasier (1993) (TV) | - |
| 1996 | N | Outstanding Lead Actor in a Comedy Series | Frasier (1993) (TV) | - |
| 1995 | W | Outstanding Lead Actor in a Comedy Series | Frasier (1993) | - |
| 1994 | W | Outstanding Lead Actor in a Comedy Series | Frasier (1993) (TV) | - |
| 1992 | N | Outstanding Lead Actor in a Comedy Series | Wings (1990) (TV) | - |
| 1990 | N | Outstanding Supporting Actor in a Comedy Series | Cheers (1982) (TV) | - |
| 1988 | N | Outstanding Supporting Actor in a Comedy Series | Cheers (1982) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2012 | W | Best Performance by an Actor in a Television Series - Drama | Boss (2011) | - |
| 2002 | N | Best Performance by an Actor in a Television Series - Musical or Comedy | Frasier (1993) (TV) | - |
| 2001 | W | Best Performance by an Actor in a TV-Series - Comedy/Musical | Frasier (1993) (TV) | - |
| 1999 | N | Best Performance by an Actor in a TV-Series - Comedy/Musical | Frasier (1993) (TV) | - |
| 1998 | N | Best Performance by an Actor in a TV-Series - Comedy/Musical | Frasier (1993) (TV) | - |
| 1997 | N | Best Performance by an Actor in a TV-Series - Comedy/Musical | Frasier (1993) (TV) | - |
| 1996 | W | Best Performance by an Actor in a TV-Series - Comedy/Musical | Frasier (1993) (TV) | - |
| 1995 | N | Best Performance by an Actor in a TV-Series - Comedy/Musical | Frasier (1993) (TV) | - |
| 1994 | N | Best Performance by an Actor in a TV-Series - Comedy/Musical | Frasier (1993) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2005 | N | Most Inspiring Television Acting | A Christmas Carol (2004) (TV Movie) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2002 | W | Favorite Male Television Performer | Frasier (1993) | - |
| 1994 | W | Favorite Male Performer in a New TV Series | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2015 | W | Worst Supporting Actor | The Expendables 3 (2014), Legends of Oz: Dorothy's Return (2014), Think Like a Man Too (2014) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2002 | W | Best Performance by an Actor in a Series, Comedy or Musical | Frasier (1993) (TV) | - |
| 1999 | N | Best Performance by an Actor in a Television Series - Comedy or Musical | Frasier (1993) (TV) | - |
| 1998 | W | Best Performance by an Actor in a Television Series - Comedy or Musical | Frasier (1993) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2004 | N | Outstanding Performance by an Ensemble in a Comedy Series | Frasier (1993) (TV) | Peri Gilpin, Jane Leeves, John Mahoney |
| 2003 | N | Outstanding Performance by an Ensemble in a Comedy Series | Frasier (1993) (TV) | Peri Gilpin, Jane Leeves, John Mahoney |
| 2002 | N | Outstanding Performance by a Male Actor in a Comedy Series | Frasier (1993) (TV) | - |
| 2002 | N | Outstanding Performance by an Ensemble in a Comedy Series | Frasier (1993) (TV) | Peri Gilpin, Jane Leeves, John Mahoney |
| 2001 | N | Outstanding Performance by a Male Actor in a Comedy Series | Frasier (1993) (TV) | - |
| 2001 | N | Outstanding Performance by an Ensemble in a Comedy Series | Frasier (1993) (TV) | Peri Gilpin, Jane Leeves, John Mahoney |
| 2000 | W | Outstanding Performance by an Ensemble in a Comedy Series | Frasier (1993) (TV) | Peri Gilpin, Jane Leeves, John Mahoney |
| 2000 | N | Outstanding Performance by a Male Actor in a Comedy Series | Frasier (1993) (TV) | - |
| 1999 | N | Outstanding Performance by an Ensemble in a Comedy Series | Frasier (1993) (TV) | Peri Gilpin, Jane Leeves, John Mahoney |
| 1999 | N | Outstanding Performance by a Male Actor in a Comedy Series | Frasier (1993) (TV) | - |
| 1998 | N | Outstanding Performance by a Male Actor in a Comedy Series | Frasier (1993) (TV) | - |
| 1998 | N | Outstanding Performance by an Ensemble in a Comedy Series | Frasier (1993) (TV) | Peri Gilpin, Jane Leeves, John Mahoney |
| 1997 | N | Outstanding Performance by a Male Actor in a Comedy Series | Frasier (1993) (TV) | - |
| 1997 | N | Outstanding Performance by an Ensemble in a Comedy Series | Frasier (1993) (TV) | Peri Gilpin, Jane Leeves, John Mahoney |
| 1996 | N | Outstanding Performance by a Male Actor in a Comedy Series | Frasier (1993) (TV) | - |
| 1996 | N | Outstanding Performance by an Ensemble in a Comedy Series | Frasier (1993) (TV) | Peri Gilpin, Jane Leeves, John Mahoney |
| 1995 | N | Outstanding Performance by a Male Actor in a Comedy Series | Frasier (1993) (TV) | - |
| 1995 | N | Outstanding Performance by an Ensemble in a Comedy Series | Frasier (1993) (TV) | Peri Gilpin, Jane Leeves, John Mahoney |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2014 | N | Choice Movie Villain | Transformers: Age of Extinction (2014) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 1999 | N | Individual Achievement in Comedy | Frasier (1993) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2016 | W | Best Revival of a Musical | The Color Purple | - |
| 2010 | N | Best Performance by a Leading Actor in a Musical | "La Cage aux Folles" | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2001 | N | Actor of the Year in a Comedy Series | Frasier (1993) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2006 | N | Broadcaster of the Year | Frasier (1993) (TV) | - |
| 2005 | N | Classic TV Broadcaster of the Year | Frasier (1993) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2000 | N | Best Actor in a Quality Comedy Series | Frasier (1993) (TV) | - |
| 1999 | N | Best Actor in a Quality Comedy Series | Frasier (1993) (TV) | - |
| 1998 | W | Best Actor in a Quality Comedy Series | Frasier (1993) (TV) | - |
| 1997 | W | Best Actor in a Quality Comedy Series | Frasier (1993) (TV) | - |
| 1996 | W | Best Actor in a Quality Comedy Series | Frasier (1993) (TV) | - |
| 1995 | W | Best Actor in a Quality Comedy Series | Frasier (1993) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2001 | W | Television | - | - |
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