While driving, Lois (Erica Durance) accidentally hits a dog and she brings it back to the farm to heal. Clark (Tom Welling) realizes this is no ordinary dog after the pup lifts up a car to retrieve a ball. Clark and Lois learn the dog is a product of an aborted LuthorCorp experiment and is being used to commit crimes, but when Lois is kidnapped by the robbers and Clark is weakened by kryptonite, it is up to the dog to save them. Meanwhile, Lana (Kristin Kreuk) questions Jason's (Jensen Ackles) involvement in his mother's (guest star Jane Seymour) schemes.