Jane (Jaimie Alexander) struggles through dinner with Weller's (Sullivan Stapleton) sister, Sarah (Jordana Spiro), feeling pressure to become Taylor Shaw, the girl she can't remember. The stress brings on a childhood flashback: an unseen man leads Jane to a basement filled with many neglected young children and filthy mattresses. Weller struggles to cope as well, and things only get worse when his estranged father, Bill, shows up at his apartment.
After one of Jane's tattoos leads the FBI to a secret CIA black site, the team learns that a dirty bomb maker named Dodi Khalil is on the loose. Going against the wishes of CIA Deputy Director Carter, the team gains intel that Dodi's terrorist organization is planning to release a deadly isotope in New York City. Tracking the isotope's radiation, the FBI and CIA find the terrorist group hiding in a graveyard in Queens. After an intense showdown, the threat is neutralized, and the FBI takes Dodi into custody. That's when Carter intervenes; the CIA will be taking Dodi, unless, of course, Mayfair (Marianne Jean-Baptiste) wants to give up Jane. Mayfair sternly refuses, and when Carter presses, she puts her hand on her gun, leading to a tense armed standoff, CIA vs. FBI. Carter stands down, but not for long. That night, he offers to pay off Zapata's (Audrey Esparza) gambling debts in exchange for everything she knows about Jane.