The Oscar-winning actress stars in the film as Lucy Cola, an "astronaut who returns to Earth and starts to lose touch with reality in a world that now seems too small" - with parts of the tale loosely based on the troubles of real-life astronaut Lisa Nowak.
Lisa infamously wore an adult diaper while on a road trip, a detail whose omission from the film has led to backlash from some people - but Natalie admitted during an interview on "The Ellen DeGeneres Show", airing on Friday, September 27, that she's unsure why there has been such a strong reaction.
"The original story was that this woman drove across country to confront, or kidnap depending on the version, her boyfriend and his new girlfriend," Natalie explained. "And she wore a diaper so that she didn't have to stop on the way. And we didn't do that in the movie and everyone's like, 'Where's the diaper?!' Everyone is really upset to not see me in a diaper. I don't know what that's about?!".
When host Ellen DeGeneres joked that Natalie is wearing one in the film but viewers just can't see it, the mother-of-two hit back by jesting that she was actually wearing a diaper during the interview.