After saving the life of the president, two Secret Service agents find themselves abruptly transferred to Warehouse 13--a massive, top-secret storage facility in windswept South Dakota, which houses every strange artifact, mysterious relic, fantastical object and supernatural souvenir ever collected by the U.S. government.

The Warehouse's caretaker, Artie (Rubinek), charges Pete (McClintock) and Myka (Kelly) with chasing down reports of supernatural and paranormal activity in search of new objects to cache at the Warehouse, as well as helping him to control the warehouse itself.