On the series premiere, Drew, a recently divorced father, discovers he needs a kidney and finds his donor in the last person he ever would've imagined.
Drew (Thomas Middleditch) is a therapist and newly divorced dad who is faced with finding a kidney donor when he runs into Gina (Annaleigh Ashford), a rough-around-the-edges woman from his past who volunteers her own. Together, they form an unlikely and life-affirming friendship, as they begin a journey that will forever affect both of their lives. Gabby (Kether Donohue) is Gina’s best friend; Julia (Sara Rue) is Drew’s ex-wife; Maddie (Izzy G.) is Drew and Julia’s teenage daughter; and Eli (Terrence Terrell) is a new friend of Drew's who is also going through dialysis.