Production on the movie, which also features Jack Huston, has already been underway in Puerto Rico, where Quavo recently completed filming his role.
"I honestly think this movie is going to be one of the greatest to come of this time," Quavo shares in a statement to Variety.
"The experience was unbelievable for me, with Robert DeNiro and Jack Huston being so down to earth and making me feel like family."
"Gonna see me doing some stunts and a lot of what you hear from me in my raps!" he adds. "This is one of my biggest debuts I've ever had, and [I'm] so proud of what we did and to get to work with Randall who's such an amazing guy - I can't wait to do more films with him."
Quavo has previously put his acting skills to the test with small roles in TV shows like "Narcos: Mexico", "Black-ish", "Star", and "Atlanta", and Emmett is convinced he has what it takes to make it in Hollywood.
"Quavo is a superstar and a real actor," the filmmaker says. "Getting to see him bring the Coyote character to life is very exciting, and I think he is going to have a film career equally as big as his music."
He isn't the only Migos member making the transition into acting - bandmate Offset is also heading to the big screen to star in drama "American Sole", alongside actors Pete Davidson and O'Shea Jackson Jr..