The singers will field fans' song requests for "Garth & Trisha: Live!", which will be broadcast from the comfort of Studio G, the recording studio located in the couple's Nashville, Tennessee home.
Brooks has been performing regular gigs for fans via Facebook Live for the past few years, and last week (March 23), he recruited Yearwood, his wife and fellow musician, to help entertain fans stuck at home during the coronavirus chaos.
The show proved so popular, with 5.2 million fans tuning in, the session crashed a number of times, prompting the pair to play on for longer than planned.
Now Brooks and Yearwood are set to do it all again on Wednesday (April 01), only this time, the hour-long isolation special will be broadcast on U.S. network CBS from 9 P.M. EST.
The country couple is also digging deep to help those in need with a generous charity donation.
"We're seeing how big things can be when we all do them as one," Brooks and Yearwood share in a statement.
"In addition to the special, we and CBS will donate $1 million to charities to be determined, combating the COVID-19 virus."
The musicians join the likes of Angelina Jolie, Arnold Schwarzenegger, James Taylor, Kylie Jenner, and Kim Kardashian in making $1 million (£803,000) pledges to aid in the fight against the coronavirus pandemic.