The actresses will also executive produce the project, created by many of the leading players behind the award-winning adaptation of Moriarty's earlier novel, "Big Little Lies", including writer David E. Kelley.
"Nine Perfect Strangers", expected to air on streaming service Hulu in 2021, will mark McCarthy's first TV series gig since sitcom "Mike & Molly", which won the "Bridesmaids" star an Emmy for Lead Actress in a Comedy Series in 2011.
It will be co-written by Kelley, John Henry Butterworth, and Samantha Strauss, while Kelley and Butterworth will also take on showrunner duties, reports Deadline.
The drama will be set in a high-end health and wellness facility, run by director Masha, played by Kidman, who promises nine anxious city residents her resort's 10-day retreat will change their lives. McCarthy will star as one of the clients, Francis.
"Nine Perfect Strangers" was published in 2018 and spent 13 weeks on the New York Times Best Seller list.