The 'Inside the NBA' star O'Neal is mourning the loss of his sister Ayesha Harrison-Jex who has just passed away after losing her courageous battle with cancer.

AceShowbiz - Basketball great Shaquille O'Neal has lost his sister to cancer.

The Los Angeles Lakers legend was notably absent from the set of U.S. show "Inside the NBA", on which he is a panellist, on Thursday, October 24, as it was revealed his sister, Ayesha Harrison-Jex, had passed away.

"We have to tell you why you're not seeing Shaquille O'Neal here on the set tonight," co-host Ernie Johnson told viewers.

"Basically the 'Big Fella,' who I've described as 'the biggest kid in the world,' his heart is breaking tonight. He said his world revolves around his brother and two sisters. And he lost one of his sisters this morning."

Harrison-Jex had been diagnosed with cancer three years ago. She was 40.

O'Neal has yet to personally comment on the tragedy.

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