The small screen veteran has signed on to star in "Jane the Novela", opposite Jacqueline Grace Lopez.
Cross will play the star of character Jane Villanueva's novelas in the new series, created by "Jane the Virgin"'s Valentina Garza and directed by Brad Silberling.
The new show's first season will centre around a Napa Valley winery family and Lopez will double up as the heroine of the story, while Cross will play her manipulative mother, Renata.
The actress played Bree Van de Kamp on ABC's hit series "Desperate Housewives" and was also a regular on "Melrose Place" and several U.S. daytime dramas, making her the perfect choice for the world of novelas.
Last year (2018), she went public with her anal cancer battle by revealing all her hair fell out during treatment.
Marcia posted a selfie on Instagram back in September (2018) and gave fans a health update, stating: "So grateful and happy to be alive but sad that my hair fell out and is about 1 inch long now and looks cra cra. Anyone else have #hairloss due to #cancer? Talk to me. I feel you."
She added, "I am POST cancer. All good now. Hard journey, but I am HEALTHY, happy, and more present and grateful than ever. Thank you from the bottom of my ever expanding heart for all of your LOVE."
Cross returned to social media a day later and explained the previous post had really empowered her: "After posting a picture of myself here and uttering the words #cancer and #hairloss, I felt liberated, deliriously free and completely me," she wrote. "How or why this simple act gave me such a powerful lift I did not question, but I thanked God or whatever gave me the internal push to move forward and expose myself."