The rocker donated $500,000 (£386,500) to the cause and helped with the renovation of the second facility - a sister to the Janie's House, which opened in Atlanta, Georgia last year (18).
The new Tennesse campus will house 14 women and their families, annually.
The two shelters were funded by Tyler's Janie's Fund organisation, which he created to raise cash for women in need.
TICK TOCK!!!! TIME IS RUNNING OUT TO GET YOUR TIX TO MY @JaniesFund VIEWING PARTY! PLEASE JOIN ME AND @Aerosmith FOR A MUSIC FILLED NIGHT TO SUPPORT THESE WONDER GIRLS!!!
CONTACT: [email protected] pic.twitter.com/kkui0O1T5e
— Steven Tyler (@IamStevenT) 3 February 2019
At the launch of the latest Janie's House, Tyler revealed his band's hit "Janie's Got a Gun" inspired him to set up his foundation.
The doors to our Janie’s House in Memphis are officially open! Janie’s Fund is proud to work with @youthvillages and @IamStevenT, to provide brave and courageous girls with a safe haven to heal. https://t.co/fNrtfFnySc— JaniesFund (@JaniesFund) 5 February 2019
The track chronicles the story of a woman who gets revenge on her abusive father.
To date, Janie's Fund has raised almost $5 million (£3.8 million) and Tyler and his band are hoping to raise more money at the second annual Janie's Fund Grammy Awards Viewing Party on Sunday, February 10, in Los Angeles.
The event will be hosted by Jane Lynch and include a performance from Aerosmith.