The actress starred alongside Hugh Grant in the British romantic comedy as his love interest Carrie, but she will play a new character, the mother of one of the leads, in the upcoming Hulu series inspired by the film, according to Deadline.
The series, which is being written and executive produced by Mindy Kaling and Matt Warburton, was originally set to star Jessica Williams, but the lead role will now be played by Nathalie Emmanuel, best known for "Game of Thrones" and the two most recent "Fast and Furious" movies.
She will play Maya, one of four American friends who reunite for a "fabulous London wedding", but after a bombshell at the ceremony "throws their lives into turmoil, they must weather a tumultuous year of romance and heartbreak."
According to Deadline, "Relationships are forged and broken, political scandals exposed, London social life lampooned, love affairs ignited and doused, and of course, there are four weddings... and a funeral."
The group is rounded out by Nikesh Patel as Kash, John Reynolds as Duffy, and Rebecca Rittenhouse as Ainsley Howard. MacDowell will play her mother Mrs. Howard in a guest capacity.
The show is heading into production ahead of a 2019 debut.