The actress and activist has been a leading voice in the fight to end sexual misconduct in Hollywood following the downfall of producer Harvey Weinstein last year, when he became the first big name to be accused of decades of bad behaviour.
Milano is also widely credited with helping to take the #MeToo movement, which allowed victims of sexual harassment or assault to speak out online, mainstream after calling on her Twitter followers to share their experiences with others by using the hashtag in the wake of the Weinstein scandal.
Now the former "Charmed" star has revealed her activism actually gave one actress on the set of her Netflix series Insatiable the courage to ask for her support in reporting an "inappropriate comment" made to her at work.
"Three weeks after I sent out that initial tweet and we were in the height of #MeToo, an actress on my show was sexually harassed by another actor, and I had to walk with her to the producer," Alyssa told Vulture. "We got onto the phone, and we went to the studio."
Milano didn't identify the people involved in the incident or what happened to the alleged harasser, but explained the actress' agent subsequently made sure their client was "well protected" going forward.
"The only reason why it's a story is because it was just on the heels (of me) sending out a tweet that echoed through the world," Alyssa reflected. "Just the irony of that."
Netflix bosses have yet to comment on the incident on the set of "Insatiable", which stars Debby Ryan as an overweight teenager who decides to seek revenge on her bullies after undergoing an extreme diet.
The first season of the show debuted on the streaming service in August and has since been picked up for a second season.