Goody (Silverstone) and Stacy (Krysten Ritter) are addicted to the night life, clubbing, hooking up and always looking for the next thrill, all the while keeping a big a secret-they happen to be modern-day vampires. But even with lifetimes of dating experience behind them, the duo realizes they still have a lot to learn about love when Stacy unexpectedly falls for the son of a vampire hunter, and Goody runs into the man of her dreams from decades earlier.

With their destinies at stake, the girls are faced with a difficult choice; give up their eternal youth for a chance at love, or continue to live their uncomplicated fabulously single lives forever.

Vamps also features an all-star supporting cast, including Sigourney Weaver, Richard Lewis, Dan Stevens, Justin Kirk, Wallace Shawn, Marilu Henner, and Kristin Johnson.