Picking up immediately after the events in "Resident Evil: Retribution", humanity is on its last legs after Alice is betrayed by Wesker in Washington D.C. As the only survivor of what was meant to be humanity's final stand against the undead hordes, Alice must return to where the nightmare began - Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.

In a race against time Alice will join forces with old friends, and an unlikely ally, in an action packed battle with undead hordes and new mutant monsters. Between losing her superhuman abilities and Umbrella's impending attack, this will be Alice's most difficult adventure as she fights to save humanity, which is on the brink of oblivion.