Based on the eponymous graphic novel written by Jimmy Palmiotti and Justin Gray, the film follows the story of comic book creator Todd Walkley (Jesse Williams), along with his girlfriend Kathy (Jordana Brewster), assistant Aurora (Niamh Wilson) and best friend and Hard Calibre Comics owner Ezra (Jay Baruchel) as they go on a road trip.

On their way from Toronto to New York for Comic-Con, bad things start to happen and people start getting killed in a fashion eerily similar to the kills portrayed in his Slasherman comic. It becomes clear that a very avid fan is out there following them and hurting people, and using Todd's comic as inspiration. As the bodies pile up, and Todd's friends and family become targets and victims themselves, Todd will be forced into taking responsibility for everything his ideas have wrought.