Set in 19th century Baltimore, "The Institute" tells the story of Isabel Porter (Allie Gallerani), who, stricken with grief from her parents’ untimely death, voluntarily checks herself into the Rosewood Institute. Subjected to bizarre and increasingly violent pseudo-scientific experiments in personality modification, brainwashing, and mind control, she must escape the clutches of Rosewood and exact her revenge, or else be forever lost.