A crime biopic of Griselda Blanco, the pioneer in the Miami-based cocaine drug trade and underworld during the 1970s and early 1980s. Blanco, nicknamed La Madrina aka the Black Widow, was a prominent member of organized drug network Medellin Cartel. The Colombia-born woman established a cocaine business with her husband after moving to New York in mid '70s. She was allegedly involved in hundreds of assassination cases in attempt to stay on top.

Blanco was a multi-millionaire by the time she was in her 40s but served 18 years in prison after arrested in 1985. Deported back to Colombia, she was killed by a drive-by motorcyclist in Medellin, Colombia in 2012.