"Crisis" follows three colliding stories: A drug trafficker (Armie Hammer) arranges a multi-cartel Fentanyl smuggling operation between Canada and the U.S.; an architect (Evangeline Lilly) recovering from an OxyContin addiction tracks down the truth behind her son's involvement with narcotics; and a university professor (Gary Oldman) battles unexpected revelations about his employer, a drug company with deep government influence bringing a new "non-addictive" painkiller to market.