B.O.O. (Bureau of Otherworldly Operations) is the super classified agency you've never heard of and certainly never seen. Dedicated to protecting humans from evil hauntings, the agents of B.O.O. have a secret weapon: they are ghosts themselves.

When newbie agents Jackson Moss (Seth Rogen) and his odd-ball partner Watts (Melissa McCarthy) uncover a plot to destroy B.O.O. by the agency's Most Wanted Haunter, they must use every trick in their arsenal to defeat his powerful ghost army and save Earth from a ghostly fate.