With the dexterous aide of Mario Van Peebles (New Jack City, Panther, Baadassss!) in the director's seat, rapper/actor Curtis "50 Cent" Jackson undergoes an astonishing physical transformation as Deon Barnes, a promising Michigan football running back who dreams of one day getting drafted by the Miami Dolphins. A well-liked young man whose winning disposition makes him a hit with just about everybody (especially the girls), Deon has a line on a Heisman Trophy until he one day collapses in the locker room following a big win. The diagnosis, delivered by his doctor (Ray Liotta), is cancer, and Deon's blessed life comes crashing down around him as he undergoes chemotherapy, losing his hair and over 60 lbs of muscle, his hair falling out, leaving him an emaciated shadow of his former self.