Isabel (Michelle Williams) has dedicated her life to working with the children in an orphanage in Calcutta. Theresa (Julianne Moore) is the multimillionaire head of a media company who lives with her artist husband (Billy Crudup) and their twin boys in New York. When word comes to Isabel of a mysterious and generous grant for the financially struggling orphanage, she must travel to New York to meet the benefactor--Theresa--in person.