(*): W=Win, N=Nomination
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2005 | N | - | Brokeback Mountain (2005) | Heath Ledger, Jake Gyllenhaal, Anne Hathaway |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2009 | N | Best Comedic Performance | The House Bunny (2008) | - |
| 2007 | N | Best Fight | My Super Ex-Girlfriend (2006) | Uma Thurman (Super Girl Fight) |
| 2006 | N | Best Kiss | Just Friends (2005) | Chris Marquette |
| 2001 | N | Best Kiss | Scary Movie (2000) | Jon Abrahams |
| 2001 | N | Breakthrough Female Performance | Scary Movie (2000) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2018 | N | Comedy Movie Star of 2018 | Overboard (2018) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2017 | N | Favorite Comedic TV Actress | - | - |
| 2016 | N | Favorite Comedic TV Actress | - | - |
| 2014 | N | Favorite Actress in a New TV Series | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2006 | N | Outstanding Performance by a Cast in a Motion Picture | Brokeback Mountain (2005) | Heath Ledger, Jake Gyllenhaal, Michelle Williams |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2018 | N | Choice Comedy Movie Actress | Overboard (2018) | - |
| 2011 | N | Choice Movie Actress: Comedy | Take Me Home Tonight (2011) | - |
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