It's Keith (Craig Sheffer) and Jules' (guest star Maria Menounos) wedding day and the event has turned the town upside down. Brooke (Sophia Bush) asks Lucas (Chad Michael Murray) to take her to the wedding as his date, Nathan (James Lafferty) makes an important decision involving his marriage to Haley (Bethany Joy Lenz), and Jake (Bryan Greenberg) and Peyton (Hilarie Burton) take a big step in their relationship. Meanwhile, Karen (Moira Kelly) and Andy (guest star Kieran Hutchinson) discover Jules' secret relationship with Dan (Paul Johansson).