"Pick of the Litter" follows a litter of puppies from the moment they're born and begin their quest to become Guide Dogs for the Blind, the ultimate canine career. Cameras follow these pups through a two-year odyssey as they train to become dogs whose ultimate responsibility is to protect their blind partners from harm. Along the way, the dogs meet a community of dedicated individuals who train them to do amazing, life-changing things in the service of their human. The stakes are high and not every dog can make the cut. Only the best of the best. The pick of the litter.