| Rank | Week-1 | Movie Title | Total Gross | ||
| 1 |
|
|
 The ProposalSandra Bullock, Ryan Reynolds
|
$33,627,598 | $33,627,598 |
| 2 |
 |
|
The HangoverBradley Cooper, Ed Helms
|
$26,753,473 | $152,817,015 |
| 3 |
|
|
UpEdward Asner, Jordan Nagai
|
$23,492,677 | $226,268,932 |
| 4 |
|
|
Year OneJack Black, Michael Cera
|
$19,610,304 | $19,610,304 |
| 5 |
|
|
The Taking of Pelham 123Denzel Washington, John Travolta
|
$12,034,899 | $44,067,224 |
| 6 |
|
|
Night at the Museum 2: Battle of the SmithsonianBen Stiller, Amy Adams
|
$7,807,185 | $156,459,744 |
| 7 |
|
|
Star TrekChris Pine, Zachary Quinto
|
$5,511,434 | $240,255,340 |
| 8 |
|
|
Land of the LostWill Ferrell, Anna Friel
|
$4,358,945 | $44,055,510 |
| 9 |
|
|
Imagine ThatEddie Murphy, Yara Shahidi
|
$3,290,227 | $11,541,605 |
| 10 |
|
|
Terminator SalvationChristian Bale, Sam Worthington
|
$3,284,230 | $119,727,528 |
| 11 |
|
|
Angels & DemonsTom Hanks, Ayelet Zurer
|
$2,820,196 | $128,158,818 |
| 12 |
|
|
Drag Me to HellAlison Lohman, Justin Long
|
$1,974,375 | $39,234,860 |
| 13 |
 |
|
Away We GoJohn Krasinski, Maya Rudolph
|
$871,224 | $1,937,113 |
| 14 |
|
|
X-Men Origins: WolverineHugh Jackman, Liev Schreiber
|
$635,130 | $177,288,905 |
| 15 |
|
|
My Life in RuinsNia Vardalos, Richard Dreyfuss
|
$460,935 | $7,821,989 |
| 16 |
|
|
Easy VirtueJessica Biel, Colin Firth
|
$429,101 | $1,575,197 |
| 17 |
|
|
Food, Inc.Michael Pollan, Eric Schlosser
|
$288,194 | $385,920 |
| 18 |
|
|
17 AgainZac Efron, Matthew Perry
|
$278,984 | $62,730,645 |
| 19 |
|
|
Under the Sea 3DJim Carrey
|
$268,997 | $10,422,675 |
| 20 |
|
|
Whatever WorksLarry David, Evan Rachel Wood
|
$266,162 | $266,162 |
