While battling her own anxieties, therapist Emily Milburton (Jenny Slate) spends her time listening to other people's problems. Her professional and personal worlds collide when Emily's newest patient, Josh Norman (Zachary Quinto), walks through her door.

Mentally ill and experiencing hallucinations, Josh harbors complex feelings for his estranged brother, Craig (Jon Hamm). Things begin to get interesting when Emily falls for Craig.